Sildenafil is a medication used to treat erectile dysfunction (ED) in men and pulmonary arterial hypertension (PAH). It works by increasing blood flow to the penis or lungs, allowing for an erection to occur during sexual activity or for improved exercise capacity in individuals with PAH. Sildenafil belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors, which work by relaxing the blood vessels in the penis or lungs and increasing blood flow.
Sildenafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which is responsible for breaking down a chemical called cyclic guanosine monophosphate (cGMP). By inhibiting PDE5, sildenafil increases the levels of cGMP in the body, which relaxes the blood vessels in the penis and allows for increased blood flow. This increased blood flow can help improve sexual function and allow for an erection to occur during sexual activity.
Sildenafil typically lasts for about 4-6 hours in the body, but the duration of effect can vary depending on individual factors such as age, dosage, and overall health.
Sildenafil is generally considered safe and effective for the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH) when used as directed by a licensed healthcare provider.
Sildenafil is typically taken orally, with or without food, about 30-60 minutes before sexual activity. The recommended starting dose is typically 50 mg, but the appropriate dose may vary depending on individual factors such as age, health status, and other medications being taken.
Sildenafil is typically taken on an as-needed basis, about 30-60 minutes before sexual activity. It is not intended for daily use.
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