What is sildenafil

Sildenafil is a medication used to treat erectile dysfunction (ED) in men and pulmonary arterial hypertension (PAH). It works by increasing blood flow to the penis or lungs, allowing for an erection to occur during sexual activity or for improved exercise capacity in individuals with PAH. Sildenafil belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors, which work by relaxing the blood vessels in the penis or lungs and increasing blood flow.

How does sildenafil work

Sildenafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which is responsible for breaking down a chemical called cyclic guanosine monophosphate (cGMP). By inhibiting PDE5, sildenafil increases the levels of cGMP in the body, which relaxes the blood vessels in the penis and allows for increased blood flow. This increased blood flow can help improve sexual function and allow for an erection to occur during sexual activity.